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KMID : 1143420160090020026
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Public Health Weekly Report
2016 Volume.9 No. 2 p.26 ~ p.36
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Prevalence of Respiratory Viruses in Patients with Acute Respiratory Infections, 2014
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Jung Hee-Dong
Chung Hyang-Min
Kim Sung-Soon
Kim Ki-Soon
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Abstract
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Acute Respiratory Infections (ARI) that causes significant morbidity and mortality with consequently an enormous economic burden on society are the most common infectious disease of humans worldwide.
Since Dec 2005, Korea Centers for Disease Control and Prevention (KCDC) has been running surveillance system for the detection of major respiratory viruses causing ARI. A research network for ARI including influenza-like illness (ILI), year-round surveillance system named in KINRESS (Korea Influenza and Respiratory Viruses Surveillance System) was established in Korea.
In this study, to investigate the viral pathogen causing ARI, multiplex PCR/RT-PCR was performed on respiratory specimens (throat or nasal swab) collected from the ARI patients. And the statistical analysis was performed to investigate the characteristics of age-distribution, seasonality, and clinical features of ARI patients with respiratory virus infection in Korea, 2014.
We performed multiplex PCR/RT-PCR on respiratory specimens (throat swab) to determine the prevalence of 14 viruses including adenovirus (HAdV), parainfluenza virus (HPIV) 1, 2, 3, respiratory syncytial virus (HRSV) A and B, influenza virus (IFV) H1N1pdm09, H3N2, B, human coronavirus (HCoV) 229E, NL63 and OC43, human rhinovirus (HRV), human bocavirus (HBoV) and human metapneumovirus (HMPV). Respiratory viruses were detected by 57.1% of enrolled patients(n=10,696) in 2014. The specimen obtained from ARI patients, 1-5 year-old age group accounted for almost. However, virus detection rate was not significantly different by the age group. HAdV, HPIV, HRSV, HCoV, HBoV and HMPV were mainly detected from under 5 years old. IFV were mainly detected on over 6 years old. HRSV, IFV and HCoV infections peaked on winter season. In summer, incidence of HPIV and HBoV were increased. When we analyzed the association of viral infection with clinical feature, almost infections were correlated with fever, cough and runny nose. Our data suggest that there was a meaningful relationship between viral infection and typical manifestation of known clinical feature as well as seasonality and age distribution.
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KEYWORD
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